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  • Title: [Role of the striatum in the influence of serotoninergic substances on the course of corazole seizures in rats].
    Author: Avakian RM.
    Journal: Biull Eksp Biol Med; 1976 Jul; 82(7):789-92. PubMed ID: 133738.
    Abstract:
    The effect of 5-oxytryptophane (5-OT) and of parachlor-phenylalanine (pCPA) on the behaviouristic EEG manifestations of metrazol convulsions in electrostimulation and destruction of the striatum was studied. The effect of the preparations on the myoclonia and the spike-wave rhythm caused by metrazol did not largely depend on the functional condition of the corpus striatum. The capacity of 5-OT to facilitate, and of pCPA to aggravate the course of generalized convulsions and of the postconvulsive state became enhanced in stimulation and was eliminated after the destruction of the striatum.
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