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  • Title: Detection of human papillomavirus DNA in seborrheic keratosis by polymerase chain reaction.
    Author: Zhu WY, Leonardi C, Penneys NS.
    Journal: J Dermatol Sci; 1992 Nov; 4(3):166-71. PubMed ID: 1337468.
    Abstract:
    We searched for HPV DNA in 72 cases of seborrheic keratosis (nongenital SK 29, genital SK 43) using polymerase chain reaction. Amplification of HPV DNA was found in 24 (nongenital, 1; genital, 23). HPV DNA type 6 was present in 18 cases and type 11 in four and type 33 in two. Twenty-three (53%) cases of genital region SK and one (3%) case of nongenital region SK contained HPV DNA sequences. Histopathologically, the perinuclear vacuolization of epithelial cells, mitosis and dyskeratotic cells were more marked in HPV DNA-positive SK than those in negative SK (P < 0.01). We suppose HPV may play an important role in epidermal proliferation of SK in the genital region.
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