These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hydroxyl radical generation in the NADH/microsomal reduction of vanadate.
    Author: Shi X, Dalal NS.
    Journal: Free Radic Res Commun; 1992; 17(6):369-76. PubMed ID: 1337535.
    Abstract:
    ESR spin trapping measurements demonstrate generation of hydroxyl (.OH) radical from reduction of vanadate by rat liver microsomes/NADH without exogenous H2O2. Catalase decreases the .OH signal while increasing a vanadium (4+) signal. Addition of superoxide dismutase (SOD) or measurements under an argon atmosphere show decreased .OH radical production. The results suggest that during the one-electron vanadate reduction process by microsomes/NADH, molecular oxygen is reduced to H2O2, which then reacts with vanadium (4+) to generate .OH radical via a Fenton-like mechanism.
    [Abstract] [Full Text] [Related] [New Search]