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  • Title: Haematological and erythrocyte membrane changes induced by amiodarone, in rats.
    Author: Padmavathy B, Devraj NS, Devraj H.
    Journal: Indian J Physiol Pharmacol; 1992 Oct; 36(4):276-8. PubMed ID: 1337899.
    Abstract:
    The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.
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