These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The relationship between Na overload and Na/H exchange--a study in the isolated isovolumic rat hearts].
    Author: Zhao TC, Shi AY.
    Journal: Sheng Li Xue Bao; 1992 Oct; 44(5):510-4. PubMed ID: 1338134.
    Abstract:
    Thirty min after stabilization perfusion with oxygenated buffer, hearts were divided in four groups: (1) CONTROL GROUP: 75 min. of aerobic perfusion; (2) Low flow anoxia group: 45 min. of low flow anoxic perfusion (95% N2:5%CO2, 0.15 ml/min.) followed by 30 min. of aerobic perfusion; (3) Ouabain group: protocol same as (2), except that ouabain (200 mumol/L) was added to anoxic perfusate during low flow anoxia; (4) Ouabain+Amiloride group: protocol same as (3) except that amiloride (0.5 mmol/I) was added to perfusate during low flow anoxia. Compared with the low flow anoxia group, ouabain resulted in an additional increase in Na during reperfusion accompanied with a depressed ventricular function. The deleterious effects of ouabain could be significantly combatted by amiloride. It is concluded that a decrease in Na/K ATPase activity may contribute to Na gain in reperfused myocardium, the mechanism of which might result from stimulation of Na/H exchange.
    [Abstract] [Full Text] [Related] [New Search]