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  • Title: The effect of nizatidine on neuromuscular transmission.
    Author: Bossa R, Baggio G, Caffero L, Castelli M, Chiericozzi M, Efstathiu G, Galatulas I.
    Journal: In Vivo; 1992; 6(6):597-600. PubMed ID: 1338367.
    Abstract:
    The effect of the H2-receptor antagonist, nizatidine, on neuromuscular transmission was investigated using sciatic nerve-gastrocnemius muscle preparations of rat in vivo. Nizatidine, administered by i.v. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and the aminoglycoside antibiotic, kanamycin. Moreover, the drug alone is capable of producing a blockade on preparations stimulated at high frequency. The neuromuscular blockade induced by nizatidine is reversed by 4-aminopyridine but not by dimaprit.
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