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  • Title: [Epidermal growth factor for enhancing DNA synthesis of hepatocytes and its protecting effect on animals with liver injury].
    Author: Huang HL.
    Journal: Zhonghua Yi Xue Za Zhi; 1992 Oct; 72(10):604-7, 639. PubMed ID: 1338507.
    Abstract:
    Epidermal growth factor (EGF) was purified chromatographically from mice submaxillary glands, and its activity and electrophoretic pureness were identified. The effect of EGF, glucagon-insulin (G-Ins) and EGF-glucagon-insulin mixture(EGF-G-Ins) on stimulation of DNA synthesis in primary cultures of rat hepatocytes and their protective effect on mice with liver injury were investigated. The results showed that G-Ins had significant effect on DNA synthesis in primary hepatocyte culture; EGF showed more significant effect compared with G-Ins; and EGF-G-Ins had the best effect. EGF-G-Ins could increase the survival rate and improve the repair of injured hepatocytes in mice treated with D-galactosamine. Although EGF and G-Ins could reduce the degree of hepatic injury, they did not elevate the survival rate. The present study provided some information on clinical therapy with EGF-G-Ins in patients with fulminant hepatic failure.
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