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  • Title: [Diagnosis of activity in Crohn's disease and ulcerative colitis: scintigraphy with TC-99m glucoheptonate labelled leukocytes].
    Author: Orellana P, Ríos L, Gajardo P, Olea E, Oritz V, Nagel J, Quintana C, Gil MC.
    Journal: Rev Med Chil; 1992 Sep; 120(9):1006-10. PubMed ID: 1340976.
    Abstract:
    We evaluated a pre-tinning leukocyte labeling technique using Glucoheptonate-Sn lyophilized kit, in the detection of activity in 15 patients with clinical and laboratory signs of active inflammatory bowel disease (IBD). 25 patients, without gastrointestinal disease were the control group. In 7/8 patients with Crohn's disease and in 7/7 with Ulcerative Colitis the study was positive. The negative study corresponded to a patient who has only involvement of the duodenum, an area of difficult evaluation due to the high liver uptake. 3/25 patients of the control group had activity in the intestine at 4 hour images. In spite of the small group evaluated, we believe that this labeling technique is a promising procedure for evaluation of activity in patients with IBD (Sensitivity 93.3%, Specificity 88.0%).
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