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  • Title: Neurologically active peptides.
    Author: Barbeau A, Gonce M, Kastin AJ.
    Journal: Pharmacol Biochem Behav; 1976; 5(Suppl 1):159-63. PubMed ID: 13415.
    Abstract:
    This paper reviews recent evidence that a number of small peptides found in the brain are active in the central nervous system and behaviorally. Attention is focused on MSH/ACTH 4-10, alpha- and beta-MSH, and the prohormone beta-LPH, as they produce a syndrome of yawning and stretching. Studies with substance P and mainly with MIF-I are also reviewed. It is shown that substance P is an excitatory transmitter or modulator in the dorsal spinal cord with that MIF-I has antiparkinson properties. It is concluded that many polypeptides have direct actions on the central nervous system independent of their neuroendocrine properties.
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