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  • Title: Effect of OK-432 on cytotoxic activity in cancer patients without tumor burden.
    Author: Fujieda S, Saito H, Isobe Y, Nakagawara G, Nishi O, Nagahara K, Watanabe Y, Hoshino T.
    Journal: Anticancer Res; 1992; 12(6B):1941-5. PubMed ID: 1341892.
    Abstract:
    The present study was designed to determine the optimal therapeutic protocol for OK-432, a streptococcal preparation, and to clarify the kinetics of various immunological parameters following intracutaneous administration of OK-432 in 39 disease-free postoperative patients with early cancer. These patients were randomly divided into 4 groups according to the dose (1KE or 5KE) and the frequency of administration (one or 3 times every other day) of OK-432. NK activity 3-4 days after the first injection increased significantly in patients whose pretreatment baseline activity was below the lower level of normal values (60 LU) in all study groups (P < 0.05). The elevation of post-therapeutic NK activity lasted for 2 weeks in the group of patients given repeated injections. The serum content of cytotoxic activity against L-M cells increased significantly after the injection of OK-432 at doses of more than 5 KE doses (p < 0.05). These findings suggest that repeated injections of OK-432 over a period of a week have important immunotherapeutic results.
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