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  • Title: [The enhancement of the efficacy of adriamycin by using hepatoprotectors of plant origin in metastases of Ehrlich's adenocarcinoma to the liver in mice].
    Author: Udintsev SN, Krylova SG, Fomina TI.
    Journal: Vopr Onkol; 1992; 38(10):1217-22. PubMed ID: 1343148.
    Abstract:
    It was shown that the use of an anthracycline antibiotic--adriamycin in mice with metastatic involvement resulted in pronounced liver dysfunction, as suggested by a sharp increase in blood transaminase levels. In the same model, a hepatoprotector of plant origin--Rhodiola rosea extract--was shown to inhibit tumor dissemination. Combined application of adriamycin and the extract proved no inferior in terms of antimetastatic efficacy and nearly free from toxicity.
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