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  • Title: Protective effect of radio-detoxified endotoxin (Tolerin) on the ultrastructure of pancreas in experimental endotoxin shock of rats.
    Author: Bende S, Bertók L, Bende S.
    Journal: Acta Chir Hung; ; 33(1-2):197-208. PubMed ID: 1343463.
    Abstract:
    The ultrastructural changes of pancreas exocrine cells were studied after the intravenous administration of endotoxin (LPS) or radio-detoxified endotoxin (150 kGy 60Co-gamma irradiated: RD-LPS or Tolerin). The LPS (1 mg/rat) induces an autolytic destruction in the membranes of the mitochondria of the pancreas exocrine cells. The RD-LPS given in similar dose does not produce any autolytic change. However, a small dose (100/micrograms/rat) of RD-LPS (Tolerin) as a pretreatment can protect the autolytic destruction of the mitochondria induced by LPS. This may be attributed to the membrane stabilizing effect of RD-LPS.
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