These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Chloroquine inhibits the insulin binding and the imprinting of nuclear envelope in Tetrahymena.
    Author: Hegyesi H, Kovács P, Csaba G.
    Journal: Acta Microbiol Hung; 1992; 39(3-4):289-93. PubMed ID: 1343942.
    Abstract:
    Chloroquine possessing lysosomotrop effects inhibits the development of insulin imprinting both on the plasma membrane and the nuclear envelope. Simultaneously chloroquine can inhibit the insulin binding in the nucleus itself but not in the plasma membrane. There is a dose dependent increase of binding of labelled insulin to the nuclear envelope. The control related binding of nuclei pretreated with insulin or chloroquine is similar and have a direct ratio, independently of the applied concentrations.
    [Abstract] [Full Text] [Related] [New Search]