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  • Title: [Kinetic properties of the Ca2+--ATPase in the skeletal muscle sarcolemma of the rabbit normally and in E-avitaminotic dystrophy].
    Author: Kosterin SA.
    Journal: Ukr Biokhim Zh; 1976; 48(3):378-83. PubMed ID: 134481.
    Abstract:
    The article deals with values of seeming Michaelis' constants (for ATP) obtained at different temperatures and Michaelis' constants (for Ca ATP) obtained at 30degrees C with pathology and in norm for sarcolemma Ca2+-ATPase. It follows from the analysis of the Ca2+ total concentration effect (the ATP total concentration being constant) on the activation energy of ATP hydrolysis reactions that with pathology sarcolemma possesses, evidently, a greater adsorption affinity to Ca2+ (the enzyme activator) than in norm. The thermoinactivation properties of the enzyme are studied. It is shown that the inactivation coefficient with pathology increases more rapidly with a temperature rise than in norm. It indicates to the fact that the enzyme from the dystrophic muscles is more labile to the heat effect than from the normal ones.
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