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  • Title: Effect of truncal vagotomy and pyloroplasty on rat gastric mucosal H,K-ATPase and HCO3-ATPase activities.
    Author: Leibur M, Kengsepp AT, Roosaar P.
    Journal: Acta Chir Hung; ; 33(3-4):257-64. PubMed ID: 1345384.
    Abstract:
    The effect of truncal vagotomy and pyloroplasty on rat gastric mucosal H,K-ATPase and HCO3-ATPase activities was studied 15 and 30 days past the operation. A significant decrease in gastric body mucosal H,K-ATPase activity occurred 15 days after vagotomy, compared with pyloroplasty (p < 0.05) and non-operated control rats (p < 0.01). A recovery in the enzyme activity on the 30th postoperative day occurred. Gastric body and antral mucosal HCO3-ATPase activity was significantly (p < 0.01) decreased 15 and 30 days after vagotomy and pyloroplasty, compared with pyloroplasty controls. The observed changes in gastric mucosal H,K-ATPase and HCO3-ATPase activities after vagotomy reflect the decrease in gastric acid secretion, as well as the possible changes in mucosal bicarbonate secretion and acid-base status. A gradual recovery in mucosal H,K-ATPase activity after vagotomy may occur.
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