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  • Title: Isolation and mapping of 68 RFLP markers on human chromosome 6.
    Author: Saito S, Okui K, Tokino T, Oshimura M, Nakamura Y.
    Journal: Am J Hum Genet; 1992 Jan; 50(1):65-70. PubMed ID: 1346080.
    Abstract:
    We have isolated 68 new RFLP markers on human chromosome 6. Of these, 64 were localized on chromosomal bands by the fluorescent in-situ hybridization (FISH) method, 25 on the short arm and 39 on the long arm. Their distribution was uneven; the markers were localized predominantly in regions of R-positive banding. Eleven markers defined VNTR loci. This expanded collection of DNA markers will contribute to high-resolution linkage mapping of genes causing inherited disorders and will provide useful reagents for isolation of putative tumor-suppressor genes on chromosome 6 that appear to be involved in malignancies. Furthermore, the new markers will be guideposts for detailed linkage and physical maps of this chromosome.
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