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  • Title: Somatostatin in the management of gastrointestinal fistulas. A multicenter trial.
    Author: Torres AJ, Landa JI, Moreno-Azcoita M, Argüello JM, Silecchia G, Castro J, Hernandez-Merlo F, Jover JM, Moreno-Gonzales E, Balibrea JL.
    Journal: Arch Surg; 1992 Jan; 127(1):97-9; discussion 100. PubMed ID: 1346491.
    Abstract:
    To evaluate the effectiveness of treatment with total parenteral nutrition (TPN) alone (group A) or combined with continuous intravenous infusion of somatostatin (group B) in postoperative gastrointestinal fistulas, a multicenter, controlled and prospective randomized trial was designed. We present the results obtained after the evaluation of 40 cases (group A, n = 20; group B, n = 20). No significant differences among these treatment schedules were observed in the percentage of closure of fistulas (group A, 81.25%; group B, 85%), but patients treated with total parenteral nutrition plus somatostatin had the fistulas close within a significantly shorter period of time. Moreover, this treatment was associated with a significantly lower morbidity. These preliminary results indicate that somatostatin is a useful therapeutic complement in the conservative treatment of patients with gastrointestinal fistulas.
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