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  • Title: Pipecuronium versus high dose vecuronium. I. A comparison of speed of onset and cumulation during isoflurane anaesthesia.
    Author: Harrop-Griffiths W, Fauvel N, Plumley M, Feldman S.
    Journal: Anaesthesia; 1992 Feb; 47(2):105-6. PubMed ID: 1347204.
    Abstract:
    The onset time and tendency to cumulation of pipecuronium and high-dose vecuronium were studied during nitrous oxide anaesthesia supplemented with isoflurane. Pipecuronium 0.06 mg.kg-1 had a similar duration of action to vecuronium 0.015 mg.kg-1 (42 vs 49 min). Patients who received vecuronium had a shorter onset time of neuromuscular blockade (p less than 0.01). The use of pipecuronium was associated with marked cumulation.
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