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  • Title: Pipecuronium versus high dose vecuronium. II. A comparison of speed of onset and cumulation during propofol anaesthesia.
    Author: Harrop-Griffiths W, Platt M, Hirsch N, Feldman S.
    Journal: Anaesthesia; 1992 Feb; 47(2):107-9. PubMed ID: 1347205.
    Abstract:
    The onset time and tendency to cumulation of pipecuronium and high-dose vecuronium were compared during nitrous oxide anaesthesia supplemented with a propofol infusion. Pipecuronium 0.06 mg.kg-1 had a similar duration of action to vecuronium 0.2 mg.kg-1 (49 vs 43). Patients who received vecuronium had a shorter onset time of neuromuscular blockade (p less than 0.01). Neither pipecuronium nor vecuronium showed marked cumulation.
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