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  • Title: Macroglobulinemia. II. Antisera specific for pathological macroglobulins.
    Author: KORNGOLD L, VAN LEEUWEN G.
    Journal: J Exp Med; 1957 Oct 01; 106(4):477-84. PubMed ID: 13475607.
    Abstract:
    Rabbits were immunized with three highly purified macroglobulins, from patients with macroglobulinemia. The antisera reacted with two macroglobulins with sedimentation constants of 19S and 26S of homologous antigen, and cross-reacted with the 7S and 19S globulins of normal gamma(1)-globulin and the heterologous pathological 19S macroglobulins. Exhaustive absorption of these antisera with normal gamma-globulins rendered them specific for the homologous macroglobulins. The antigenic properties of the pathological macroglobulins indicate that these proteins are abnormal.
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