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  • Title: Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1.
    Author: Isobe M, Yagita H, Okumura K, Ihara A.
    Journal: Science; 1992 Feb 28; 255(5048):1125-7. PubMed ID: 1347662.
    Abstract:
    An indefinite survival of cardiac allografts between fully incompatible mice strains was observed when monoclonal antibodies (MAbs) to intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) were simultaneously administered after the transplantation for 6 days. Mice with long-term surviving cardiac allografts accepted skin grafts from the donor-strain but rejected skin grafts from a third-party strain. Because MAbs to ICAM-1 or LFA-1 alone were insufficient for prolonged tolerance, the two MAbs probably acted synergistically to induce specific unresponsiveness. Thus, ICAM-1----LFA-1 adhesion participates in the induction of allograft rejection and MAbs may be useful as therapeutic agents.
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