These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Lack of expression of P-glycoprotein in 7 small cell lung cancer cell lines established both from untreated and from treated patients.
    Author: Milroy R, Plumb JA, Batstone P, Maclay A, Wishart GC, Hay FG, Candlish W, Adamson R, Khan MZ, Banham S.
    Journal: Anticancer Res; 1992; 12(1):193-200. PubMed ID: 1348921.
    Abstract:
    The establishment and characterisation of 7 small cell lung cancer cell lines is described. Four cell lines were established from biopsies taken from untreated patients and one of these was from primary tumour taken via the fibreoptic bronchoscope. The other three were from biopsies taken from patients who had relapsed after chemotherapy. All grow as non-adherent aggregates of cell and express a range of neuroendocrine and epithelial features characteristics of small cell lung cancer cell lines. No relationship was observed between the characteristics of the cell line in vitro and the treatment status of the patient from whom the biopsy was taken. Furthermore, none of the cell lines expressed p-glycoprotein even though 3 were derived from relapse biopsies where chemotherapy included drugs associated with the multidrug resistance phenotype.
    [Abstract] [Full Text] [Related] [New Search]