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  • Title: The treatment of hairy cell leukemia: an update.
    Author: Golomb HM, Ratain MJ, Mick R, Daly K.
    Journal: Leukemia; 1992; 6 Suppl 2():24-7. PubMed ID: 1349662.
    Abstract:
    The treatment of hairy cell leukemia (HCL) requires continuing update. The role for splenectomy is extremely limited. Alfa-interferon therapy has been available and utilized for five years; there have been few complete remissions. The experience with Pentostatin has resulted in a majority of clinical complete remissions after several months of therapy, but persistence of a small percentage of hairy cells in the bone marrow. The most recent therapeutic agent, 2-chloro-deoxyadenosine (2-CDA) is given for seven days and results in a complete remission in the great majority of patients with no evidence of persistent bone marrow disease. If this trend persists, 2-CDA will become first line therapy for HCL as it may cure the disease.
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