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  • Title: Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.
    Author: Kim JM, Brannan CI, Copeland NG, Jenkins NA, Khan TA, Moore KW.
    Journal: J Immunol; 1992 Jun 01; 148(11):3618-23. PubMed ID: 1350294.
    Abstract:
    The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span approximately 5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.
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