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  • Title: [Prevention of migraine using bisoprolol. Results of a double-blind study versus metoprolol].
    Author: Wörz R, Reinhardt-Benmalek B, Föh M, Grotemeyer KH, Scharafinski HW.
    Journal: Fortschr Med; 1992 May 20; 110(14):268-72. PubMed ID: 1351025.
    Abstract:
    AIMS: Comparison of bisoprolol, a beta-1 selective beta blocker with no intrinsic sympathomimetic activity (ISA) and metoprolol, which numerous studies have shown to be an effective migraine prophylactic. STUDY DESIGN: Multicentric, cross-over study. PATIENTS: 125 patients suffering at least from 3 attacks of classic or common migraine a month for at least two years. TREATMENT: Bisoprolol 5 mg given once a day, or metoprolol 50 mg given twice a day, for two periods of 12 weeks. RESULTS: 125 patients were admitted to the 4-week run-in phase. A comparison of the main target: frequency of migraine attacks was thus carried out in 78 patients (f. = 63, m. = 15). Both substances reduced the average frequency of migraine per 28-day period by about 50%. There was no statistically significant difference between the two beta-blockers (p greater than 0.05). CONCLUSIONS: The results of the study show that 5 mg of bisoprolol and 100 mg of metoprolol a day have comparable efficacy for migraine prophylaxis, and show comparable tolerability.
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