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  • Title: Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity.
    Author: Burnet NG, Nyman J, Turesson I, Wurm R, Yarnold JR, Peacock JH.
    Journal: Lancet; 1992 Jun 27; 339(8809):1570-1. PubMed ID: 1351551.
    Abstract:
    The success of radiotherapy depends on the total radiation dose, which is limited by the tolerance of surrounding normal tissues. Since there is substantial variation among patients in normal-tissue radiosensitivity, we have tested the hypothesis that in-vitro cellular radiosensitivity is correlated with in-vitro normal-tissue responses. We exposed skin fibroblast cell lines from six radiation-treated patients to various doses of radiation and measured the proportions surviving. There was a strong relation between fibroblast sensitivity in vitro and normal-tissue reactions, especially acute effects. Assessment of radiosensitivity could lead to improved tumour cure rates by enabling radiation doses to be tailored to the individual.
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