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  • Title: Carbachol-induced theta-like activity in entorhinal cortex slices.
    Author: Konopacki J, Gołebiewski H, Eckersdorf B.
    Journal: Brain Res; 1992 Feb 14; 572(1-2):76-80. PubMed ID: 1351788.
    Abstract:
    The present study was conducted for two purposes: the first was to evaluate whether activation of cholinergic receptors of the entorhinal cortex in vitro (complete deafferentation) with carbachol (100 microM) was capable of producing theta (theta)-like slow activity. The second purpose was to determine whether carbachol-induced slow waveforms were mediated by muscarinic or nicotinic receptors. We demonstrated that carbachol was capable of producing theta-like slow activity. This activity was not altered by nicotinic antagonists, (+)-tubocurarine and hexametonium. Atropine and scopolamine, in contrast, completely blocked in vitro induced slow waves, indicating entorhinal muscarinic receptors to be actively involved in the mechanism generating cholinergic theta rhythm.
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