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  • Title: Vitamin A deficiency and glucocorticoid receptor activity in rat liver.
    Author: Audouin I, Garcin H, Pailler-Rodde I, Higueret P.
    Journal: J Endocrinol; 1992 May; 133(2):169-73. PubMed ID: 1351919.
    Abstract:
    The influence of vitamin A on the binding properties of hepatic glucocorticoid receptors (GR) was studied in young rats 7 weeks after they had been given a diet with or without vitamin A. Scatchard analysis showed an increased capacity of cytosolic GRs to bind dexamethasone in vitamin A deficiency. In these rats, an increase in tyrosine aminotransferase also occurred, and this could be related to the increased formation of hormone-GR complexes. Measurement of protein kinase C activity showed an increase which might be related to the functional activity of GRs.
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