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  • Title: Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary adrenal axis: CRF, ACTH and cortisol in healthy volunteers.
    Author: Beneke M, Wingender W, Horstmann R, Konrad-Dalhoff I, Weber H, Kuhlmann J, Schmidt BH.
    Journal: Eur J Clin Pharmacol; 1992; 42(2):163-9. PubMed ID: 1352246.
    Abstract:
    The neuroendocrine effects (changes in plasma CRF, ACTH and cortisol) of single and multiple (t.d.s. for 2 days) doses of ipsapirone (BAY Q 7821) 5 and 10 mg have been investigated in 6 healthy male volunteers. The study followed a balanced complete block, placebo-controlled and double blind design with two baseline phases (pre and post-treatment). Volunteers were investigated on identical days during 5 successive weeks. The results do not show a specific effect of ipsapirone on the hypothalamic-pituitary-adrenal axis when doses in the range of 5-30 mg per day were given.
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