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  • Title: [Effects of alpha 2-agonist apraclonidine on norepinephrine levels in the rat iris-ciliary body].
    Author: Hiromatsu S, Araie M, Fujimori K.
    Journal: Nippon Ganka Gakkai Zasshi; 1992 May; 96(5):580-6. PubMed ID: 1352422.
    Abstract:
    In an attempt to estimate the in vivo catecholamine level in rat iris-ciliary body, animals were sacrificed by microwave irradiation which rapidly inactivates metabolic enzymes. Catecholamine levels in the iris-ciliary body were determined by high-performance liquid chromatography with electrochemical detection. The norepinephrine level in rat iris-ciliary body per gram tissue protein was 3.56 +/- 0.22 micrograms/g (21.1 +/- 1.3 nmol/g)(mean +/- SEM, n = 7). Neither dopamine nor epinephrine were detected. A single instillation of 5 microliters of an 0.05% apraclonidine (alpha 2-agonist) to one eye of a rat increased the norepinephrine level in the iris-ciliary body by 7.7% one hour after administration (p less than 0.05).
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