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  • Title: Nitroprusside-sensitive and insensitive guanylate cyclases in retinal rod outer segments.
    Author: Margulis A, Sharma RK, Sitaramayya A.
    Journal: Biochem Biophys Res Commun; 1992 Jun 30; 185(3):909-14. PubMed ID: 1352682.
    Abstract:
    Rod outer segments of retina contain guanylate cyclase activity both in the cytosol and membrane fractions. Though the activity in the cytosol is a small fraction of the total activity, it is highly activated by nitroprusside, a nitric oxide generating agent. The membrane guanylate cyclase on the other hand is unaffected by nitroprusside both before and after solubilization. The effects of nitroprusside or nitric oxide on photoreceptor function should therefore be mediated by the cytosolic and not the membrane guanylate cyclase.
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