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  • Title: Inhibitory effect of somatostatin on abnormal GH response to TRH in primary hypothyroidism.
    Author: Baldini M, Catania A, Orsatti A, Manfredi MG, Motta P, Cantalamessa L.
    Journal: Exp Clin Endocrinol; 1992; 99(2):80-3. PubMed ID: 1353454.
    Abstract:
    Thyrotropin releasing hormone (TRH) does not promote GH secretion in normal subjects but it stimulates GH in a proportion of hypothyroid patients. In this study the response of GH to thyrotropin releasing hormone (TRH) was evaluated in 21 patients with primary hypothyroidism of different origin: 12 with autoimmune thyroiditis, 3 idiopathic, 3 congenital, 3 iatrogenic. 11 of these patients had never been treated, the others were tested after a drug-free period of at least two weeks. Basal plasma concentration of GH was normal in all patients; after TRH administration, a significant increase in plasma GH was observed in 4 patients. In these responsive patients, somatostatin infusion inhibited the abnormal GH response to TRH. It is suggested that the abnormal GH response to TRH in primary hypothyroidism might be caused by a relative deficiency of somatostatinergic control, which is corrected by exogenous somatostatin administration.
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