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  • Title: [Pharmacologic profile of urapidil. Consequences for use as an antihypertensive drug].
    Author: van Zwieten PA.
    Journal: Fortschr Med; 1992 Jun 20; 110(17):330-2. PubMed ID: 1353745.
    Abstract:
    Urapidil, a phenylpiperazine-substituted derivative of uracil, is an example of an anti-hypertensive which lowers elevated blood pressure via at least two different mechanisms. As such, it belongs to the multifactorial or hybrid anti-hypertensives. Urapidil is a peripherally acting alpha 1-adrenoceptor antagonist, and, in this regard, is comparable with prazosin and its successor compounds (e.g. doxazosin). In addition, urapidil lowers elevated blood pressure via a central mechanism which is new and differs from that of the classical antihypertensives with a central nervous effect (clonidine, etc.). This additional mechanism favourably influences the side effect profile of urapidil.
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