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  • Title: Combined effect of fascioliasis and diethylnitrosamine carcinogenesis on the activity of the rat liver monooxygenase system.
    Author: Tsocheva NT, Kadiiska MB, Poljakova-Krusteva OT, Krustev LP, Yanev SS, Stoytchev TS.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1992 Apr; 101(3):475-9. PubMed ID: 1354124.
    Abstract:
    1. The activity of the rat liver monooxygenase system after single and combined treatment with Fasciola hepatica and diethylnitrosamine (DENA) has been studied in a 27-week experiment. 2. The changes in lever drug metabolism were due mainly to F. hepatica with DENA having a modulating effect only. 3. The results are discussed with reference to earlier data of ours concerning the effects of stimulation or inhibition of DENA-induced liver carcinogenesis against a background of acute or chronic fascioliasis.
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