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  • Title: An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere.
    Author: Brannan CI, Gilbert DJ, Ceci JD, Matsuda Y, Chapman VM, Mercer JA, Eisen H, Johnston LA, Copeland NG, Jenkins NA.
    Journal: Genomics; 1992 Aug; 13(4):1075-81. PubMed ID: 1354638.
    Abstract:
    We have used an interspecific backcross between C57BL/6J and Mus spretus to derive a molecular genetic linkage map of chromosome 15 that includes 25 molecular markers and spans 93% of the estimated length of chromosome 15. Using a second interspecific backcross that was analyzed with a centromere-specific marker, we were also able to position our map with respect to the chromosome 15 centromere. This map provides molecular access to many discrete regions on chromosome 15, thus providing a framework for establishing relationships between cloned DNA markers and known mouse mutations and for identifying homologous genes in mice and humans that may be involved in disease.
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