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  • Title: Differential effect of griseofulvin on interferon-gamma-induced HLA-DR and intercellular adhesion molecule-1 expression of human keratinocytes.
    Author: Tamaki K, Saitoh A, Yasaka N.
    Journal: Br J Dermatol; 1992 Sep; 127(3):258-61. PubMed ID: 1356410.
    Abstract:
    Interferon-gamma (IFN-gamma) induces major histocompatibility complex (MHC) class II antigen and intercellular adhesion molecule-1 (ICAM-1) expression on human epidermal keratinocytes. Griseofulvin, an extensively used antifungal agent, has been used effectively in the treatment of lichen planus, in which keratinocytes express both HLA-DR and ICAM-1 antigens. In this study, we investigated the effect of griseofulvin on IFN-gamma-induced MHC class II antigen and ICAM-1 expression of keratinocytes, and demonstrated that griseofulvin decreased IFN-gamma-induced HLA-DR but not ICAM-1 expression.
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