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  • Title: Establishment of the human BSMZ breast cancer cell line, which overexpresses the erbB-2 and c-myc genes.
    Author: Watanabe M, Tanaka H, Kamada M, Okano JH, Takahashi H, Uchida K, Iwamura A, Zeniya M, Ohno T.
    Journal: Cancer Res; 1992 Oct 01; 52(19):5178-82. PubMed ID: 1356615.
    Abstract:
    A new cell line, designated BSMZ, was established from a malignant pleural effusion from a woman with breast cancer. This line has a doubling time of 27 h and has now been cultured for over 120 passages. The large, rounded BSMZ cells grow as both a monolayer and as aggregations in suspension. Intracytoplasmic lumen, a finding consistent with results from cells derived from mammary tissue, was detected on ultrastructural analysis. Injection of BSMZ cells into nude mice resulted in the growth of solid tumors 4 weeks after inoculation. The solid tumor was identical to the original BSMZ cells in microscopic and electron microscopic studies. These cells possess an average of 80 chromosomes. Expression of erbB-2 and c-myc genes was increased by 10-fold, while there was no detectable overexpression of the N-ras and c-myb genes. Southern analysis has revealed amplification of the erbB-2 and c-myc loci. The BSMZ cell line may therefore provide a useful model for the study of human breast cancer and overexpression of the erbB-2 gene.
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