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  • Title: Nonlinkage of 16q markers to familial predisposition to Wilms' tumor.
    Author: Huff V, Reeve AE, Leppert M, Strong LC, Douglass EC, Geiser CF, Li FP, Meadows A, Callen DF, Lenoir G.
    Journal: Cancer Res; 1992 Nov 01; 52(21):6117-20. PubMed ID: 1356625.
    Abstract:
    Wilms' tumor (WT), a childhood cancer of the kidney, occurs in both familial and sporadic forms. Chromosome 11 genes have been implicated in the etiology of WT, and mutations in a gene at chromosomal band 11p13, WT1, have been identified in a few WT cases. However, 11p13 has been excluded as the site of the predisposition mutation segregating in several large WT families, which implies the existence of a non-11p familial predisposition gene. Recently, loss of heterozygosity for 16q markers located between chromosomal bands 16q13 and 16q22 has been reported in approximately 20% of sporadic Wilms' tumors. To determine if this region of 16q harbors the non-11p familial WT gene, a genetic linkage study of five WT families was undertaken. Using multipoint analyses, we ruled out genetic linkage of familial WT predisposition to 16q.
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