These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of pyridine aldoximes on response of frog rectus muscle to acetylcholine.
    Author: FLEISHER JH, HOWARD JW, CORRIGAN JP.
    Journal: Br J Pharmacol Chemother; 1958 Sep; 13(3):288-90. PubMed ID: 13584730.
    Abstract:
    The effects of pyridine-2, 3- and 4-aldoxime methiodide (PAM) on the isotonic contracture of the isolated frog rectus abdominis muscle elicited by acetylcholine have been studied. The potentiation to acetylcholine resulting from incubation with PAM isomers is reversible and may be related to the weak anticholinesterase property of these compounds. Concentrations of the isomers higher than those needed for maximal potentiation produce a reversible block of the muscle to acetylcholine. pH studies suggest that cations are responsible for the potentiating and blocking properties of the PAM isomers.
    [Abstract] [Full Text] [Related] [New Search]