These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Dipeptidylpeptidase IV in human leukemic B- and T-cells.
    Author: Bylinkina VS, Lokshina LA, Samojlova RS, Lubkova ON, Gureeva TA, Golubeva NV.
    Journal: Biochem Int; 1992 Oct; 28(1):31-9. PubMed ID: 1359891.
    Abstract:
    Dipeptidylpeptidase IV (DPP-IV) activity in lymphoid cells of patients with various lymphoproliferative diseases has been assayed. The enzyme activity was detected in lysates of all leukemic T- and B-cells studied. High DPP-IV activity levels (5-7 fold higher than those in mature Th and Ts) were found in T-cells with phenotypes corresponding either to the early thymic stages of maturation, or to activated T-lymphocytes, or to some atypic T-cells. In most leukemic B-cells with phenotypes of mature and late B-lymphocytes, the DPP-IV activity was lower than in mature T-cells; however, in some B-cells carrying the activation markers CD 25 and CD 30 the activity was rather high. High DPP-IV activity was seen in the majority of leukemic B-cells expressing CD 25 (87%) and CD 11c (82%) antigens. Experiments with intact cells have shown that DPP-IV is present in the plasma membrane of leukemic B- and T-cells studied. Thus DPP-IV cannot be considered as a marker of activated T-cells alone because a significant DPP-IV activity was also detected in a number of activated leukemic B-cells and in early T-cells.
    [Abstract] [Full Text] [Related] [New Search]