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  • Title: Gamma-COP, a coat subunit of non-clathrin-coated vesicles with homology to Sec21p.
    Author: Stenbeck G, Schreiner R, Herrmann D, Auerbach S, Lottspeich F, Rothman JE, Wieland FT.
    Journal: FEBS Lett; 1992 Dec 14; 314(2):195-8. PubMed ID: 1360908.
    Abstract:
    Constitutive secretory transport in eukaryotes is likely to be mediated by non-clathrin-coated vesicles, which have been isolated and characterized [(1989) Cell 58, 329-336; (1991) Nature 349, 215-220]. They contain a set of coat proteins (COPs) which are also likely to exist in a preformed cytosolic complex named coatomer [(1991) Nature 349, 248-250]. From peptide sequence and cDNA structure comparisons evidence is presented that one of the subunits of coatomer, gamma-COP, is a true constituent of non-clathrin-coated vesicles, and that gamma-COP is related to sec 21, a secretory mutant of the yeast Saccharomyces cervisiae.
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