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  • Title: Complement factor 2 deficiency: a clinical and serological family study.
    Author: D'Cruz D, Taylor J, Ahmed T, Asherson R, Khamashta M, Hughes GR.
    Journal: Ann Rheum Dis; 1992 Nov; 51(11):1254-6. PubMed ID: 1361318.
    Abstract:
    Inherited complement deficiencies are associated with a variety of connective tissue diseases. A family with inherited deficiency of complement factor 2 (C2) is described in which two family members with homozygous C2 deficiency developed cutaneous vasculitis and sicca syndrome. The other family members had heterozygous C2 deficiency and each member had the HLA-A25, B18, DR2 (w15) haplotype. The mother had seropositive rheumatoid arthritis. Further studies showed the presence of cryoglobulins, antibodies against endothelial cells, and anticardiolipin antibodies.
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