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  • Title: Decrease by psychotropic drugs and local anaesthetics of membrane fluidity measured by fluorescence anisotropy in Escherichia coli.
    Author: Tanji K, Ohta Y, Kawato S, Mizushima T, Natori S, Sekimizu K.
    Journal: J Pharm Pharmacol; 1992 Dec; 44(12):1036-7. PubMed ID: 1361554.
    Abstract:
    The effects of psychotropic drugs and local anaesthetics on the fluidity of Escherichia coli cell membranes were examined. Chlorpromazine was shown to increase 1,6-diphenyl-1,3,5-hexatriene fluorescence anisotropy, indicating that it decreased the membrane fluidity. This increase was significant at a temperature of more than 24 degrees C. Dibucaine, lignocaine, imipramine, tetracaine and procaine also increased the fluorescence anisotropy.
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