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  • Title: Oral D2O administration and enzymatic changes in rat testis.
    Author: Kanwar KC, Verma R.
    Journal: Acta Biol Med Ger; 1976; 35(5):577-81. PubMed ID: 136164.
    Abstract:
    Heavy water caused marked gradual decrease in the weight of the body as well as the testes throughout the treatment interval ranging from 1 to 6 weeks. Following D2O oral administration, an overall significant fall in the activity of acid phosphatase and glucose-6-phosphatase was registered. On the other hand, the activity of lactic and succinic dehydrogenases, alkaline phosphatase and adenosine triphosphatase increases following D2O treatment. These changes in the enzyme activity are suggestive of an altered metabolism of the testes in response to D2O administration. Our data corroborate the view that biological systems do discriminate between H2 and D2. Oral heavy water (D20) administration and enzymatic changes were studied in rat testis. D20 caused marked gradual decrease in the weight of the body as well as the testes throughout the treatment interval ranging from 1 to 6 weeks. Following D20 oral administration, an overall marked fall in the activity of acid phosphatase and glucose-6-phosphatase was seen. However,, the activity of lactic and succinic dehydrogenases, alkaline posphatase, and adenosine triphosphatase increased following treatment. These results suggest on altered metabolism of the testes in response to D20 administration and corroborate the view that biological systems do discriminate between hydrogen and deuterium.
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