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  • Title: Expression of D2 dopamine receptor mRNA in the arterial chemoreceptor afferent pathway.
    Author: Czyzyk-Krzeska MF, Lawson EE, Millhorn DE.
    Journal: J Auton Nerv Syst; 1992 Nov; 41(1-2):31-9. PubMed ID: 1362730.
    Abstract:
    Dopamine is a major neurotransmitter in the arterial chemoreceptor pathway. In the present study we wished to determine if messenger RNAs for dopamine D1 and D2 receptor are expressed in carotid body (type I cells), in sensory neurons of the petrosal ganglion which innervate the carotid body and in sympathetic neurons of the superior cervical ganglion. We failed to detect D1 receptor mRNA in any of these tissues. However, we found that D2 receptor mRNA was expressed by dopaminergic carotid body type I cells. D2 receptor mRNA was also found in petrosal ganglion neurons that innervated the carotid sinus and carotid body. In addition, a large number of sympathetic postganglionic neurons in the superior cervical ganglion expressed D2 receptor mRNA.
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