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  • Title: Pharmacology of antitumor agents from higher plants.
    Author: Sieber SM, Mead JA, Adamson RH.
    Journal: Cancer Treat Rep; 1976 Aug; 60(8):1127-39. PubMed ID: 136296.
    Abstract:
    Some pharmacologic properties of nine antitumor agents from higher plants are described. The agents are vincristine, vinblastine the epiodophyllotoxin derivatives VM-26 and VP-16-213, maytansine, bruceantin, thalicarpine, camptothecin, and lapachol. When sufficient information is available, the agents are discussed with regard to their antitumor activity, mechanism of action, pharmacologic disposition, structure-activity relationships, and toxicity.
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