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  • Title: [A comparative analysis of the antihypertensive activity of calcium antagonists and adrenoblockers in long-term treatment].
    Author: Svishchenko EP, Kupchinskaia EG, Zanozdra NS, Bezrodnaia LV, Radchenko VV.
    Journal: Klin Med (Mosk); 1992; 70(11-12):34-7. PubMed ID: 1363481.
    Abstract:
    Essential hypertension stage II was treated by calcium antagonists, alpha- and beta-adrenoblockers in 362 patients. The drugs were compared for hypotensive efficiency at rest and exercise. A significant hypotensive effect was achieved in 81%, 58%, 44%, 43% and 37% of patients treated with labetalol, nifedipine, nadolol, propranolol, diltiazem, respectively. An increase in verapamil daily dose from 240 to 600 mg led to a rise in efficacy from 27 to 75% without an increase in the number of side effects. The antihypertensive effect of the drugs is shown to persist in long-term treatment as shown by exercise tests and static loads.
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