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  • Title: Reversible inhibition of interferon-induced antiviral state by deoxyadenosine.
    Author: Matsuno T, Shirasawa N, Kohno S.
    Journal: Acta Virol; 1976 Dec; 20(6):466-71. PubMed ID: 13641.
    Abstract:
    Deoxyadenosine reversibly inhibited the development of antiviral state (AVS) in chick embryo fibroblasts stimulated by interferon. Studies on cellular macromolecular syntheses in deoxyadenosine-treated cells suggested that the inhibition was related to nucleolar RNA synthesis. Reference experiments with actinomycin D and cordycepin (3'deoxyadenosine) also implied causal- or interrelation between AVS development and nucleolar RNA synthesis.
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