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  • Title: Neurochemical mechanisms of memory control.
    Author: Ilyutchenok RY, Loskutova LV, Finkelberg AL, Dubrovina NI.
    Journal: Acta Physiol Hung; 1992; 79(4):419-32. PubMed ID: 1364180.
    Abstract:
    Modulation of memory trace retrieval in emotiogenic brain structures, cortex and brainstem reticular formation by postsynaptic noradrenergic and dopaminergic drugs was found. At the initial stage of latent inhibition-a most significant mechanism of information selection-memory trace retrieval is retarded in all structures and in the cortex and the zona incerta later on. A haloperidol model of latent inhibition was obtained. Most important role of dopaminergic system in latent inhibition was shown. Inhibition of the GABA-benzodiazepine-ionophore complex by the blockade of GABA-receptors induced by bicuculline, the chloride channels by picrotoxin, the benzodiazepine receptors by flumazenil (R015-1788) and R015-3505 facilitates the memory trace retrieval damaged by amnesic agent. The dopaminergic activation enhances the dominant state and developes conditions for switching on the interferential GABA-ergic inhibition.
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