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  • Title: Phenylpyruvic acid as a possible precursor of o-hydroxyphenylacetic acid in man.
    Author: TASHIAN RE.
    Journal: Science; 1959 Jun 05; 129(3362):1553. PubMed ID: 13658992.
    Abstract:
    The oral administration of phenylpyruvic acid to human subjects results in increased urinary excretion of o-hydroxyphenylacetic acid. This demonstrates that phenylpyruvic acid may act as a precursor for o-hydroxy derivatives of phenylalanine and suggests that the formation of o-tyrosine is not necessary to account for the excretion of o-hydroxyphenylacetic acid in phenylketonuria.
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